Is there a dose response relationship between weight loss and symptom improvement in persons with knee osteoarthritis? 

The authors examined the dose-response relationship between weight reduction and pain/functional improvement in persons with symptomatic knee osteoarthritis (KOA) participating in a community-based weight loss program. Consecutive participants with KOA enrolled in the 18-week “Osteoarthritis Healthy Weight for Life” weight loss program were selected. In this completer’s type analysis, participants were assessed at baseline, 6 and 18 weeks for body weight and Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales. The dose-response relationship between weight-change categories (>10%, 7.6-10%, 5.1-7.5%, 2.6-5.0% and <2.5% of body weight loss) and change in KOOS scores was assessed by repeated measures ANOVA controlling for gender and age, body mass index (BMI), and KOOS. The Western Ontario McMaster Universities Arthritis Index (WOMAC) function score derived from the KOOS was used to assess a meaningful clinical functional improvement. 1383 (71% females) persons were enrolled. Mean (SD) age, height and weight was 64 (8.7) years, 1.66 (0.09)m and 95.1 (17.2)kg respectively. Mean BMI was 34.4 (5.2) with 82% of participants obese at baseline. 1304 (94%) achieved a >2.5% reduction in body weight. There was a significant dose-response relationship between all KOOS subscales and percentage of weight change across all weight change categories. Participants required ≥7.7% (95% CI 5.2-13.3) body weight loss to achieve a minimal clinically important improvement in function.

There is a significant dose-response relationship between percentage weight loss and symptomatic improvement. This study confirms the feasibility of weight loss as a therapeutic intervention in KOA in a community-based setting.

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