Longitudinal Change in the BODE Index Predicts Mortality in Severe Emphysema

Martinez FJ, Han MK, Andrei AC, Wise R, Murray S, Curtis JL, Sternberg A, Criner G, Gay SE, Reilly J, Make B, Ries AL, Sciurba F, Weinmann G, Mosenifar Z, DeCamp M, Fishman AP, Celli BR

The authors set out to determine how the mBODE (modified BODE – Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity) score changes in patients with lung volume reduction surgery versus medical therapy, and whether there are correlations with survival. The study found that an increase in mBODE of more than 1 point from baseline to 6, 12, and 24 months of follow-up was predictive of subsequent mortality in both groups. It is thought that change in mBODE may prove a good surrogate measure of survival in therapeutic trials in severe chronic obstructive pulmonary disease.

American Journal of Respiratory and Critical Care Medicine 2008; 178: 491-499

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