Changes in self-reported outcomes and objective physical function over 7 years in middle-aged subjects with or at high risk of knee OA

Roos M, Bremander AB, Englund M, Lohmander LS

The aim of this prospective study was to compare, measures of knee function and self-reported health, in patients at high risk of knee osteoarthritis (n=259 post meniscectomy) and in age and sex-matched controls (n=50). One-leg hop distance, number of knee bends in 30 seconds and Knee injury and Osteoarthritis Outcome Score (KOOS) were assessed at 18 and 25 years after meniscectomy. Radiographic osteoarthritis was defined as 2 on the Kellgren and Lawrence Scale. At initial assessment meniscectomy patients performed fewer knee bends and reported worse pain, function and quality of life compared to controls. Patients showed deterioration in all scores (p<0.001) compared to controls, but especially pain and one-leg hop. This deterioration was greater for function and self-reported health in females and inpatients with radiographic evidence of osteoarthritis. Being older or having greater Body Mass Index was associated with greater deterioration of function only. It is concluded that rmeniscectomy is associated with increased risk of pain, reduced knee function and self-related health especially in females, over weight patients and those with radiographic evidence of knee OA. These populations may benefit from rehabilitation.

Annals of Rheumatic Diseases, 2007, article online ahead of print

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