The incidence of complex regional pain syndrome: A population-based study

M. de Mos, A.G.J. de Bruijn, F.J.P.M. Huygen, J.P. Dieleman, B.H.Ch. Stricker and M.C.J.M. Sturkenboom

The objective of this study was to estimate the incidence of CRPS in the general population.  The results showed that the estimated overall incidence rate of CRPS was 26.2 per 100,000 person years. Females were affected at least three times more often than males. The highest incidence occurred in females in the age category of 61–70 years. The upper extremity was affected more frequently than the lower extremity and a fracture was the most common precipitating event. The observed incidence rate of CRPS is as more as four times higher than the incidence rate observed in the only other population-based study. Postmenopausal woman appeared to be at the highest risk for the development of CRPS.

Pain, Volume 129, Issues 1-2, May 2007, Pages 12-20

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