The Effect of Infliximab, a Monoclonal Antibody Against TNF-[alpha], on Disc Herniation Resorption: A Randomized Controlled Study.

Autio, Reijo A. MD; Karppinen, Jaro MD, DMSc ; Niinimaki, Jaakko MD; Ojala, Risto MD, DMSc; Veeger, Nic MSc; Korhonen, Timo MD; Hurri, Heikki MD, DMSc; Tervonen, Osmo MD, DMSc.

The objective of this study was to evaluate the effect of infliximab on herniated nucleus pulposus (HNP) resorption.  Although the effects of tumor necrosis factor alpha (TNF-[alpha]) on HNP resorption are not fully understood, TNF-[alpha] appears to be an essential mediator in HNP resorption.  The reulsts showed that HNP volume decreased significantly from baseline to 6 months in both treatment groups, with no difference noted between the infliximab and placebo groups. The authors conclude that Infliximab did not appear to interfere with disc herniation resorption over a 6-month period.

Spine.  31(23):2641-2645, November 1, 2006.

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Neck Pain

Out of all 291 conditions studied in the Global Burden of Disease 2010 Study, neck pain ranked 4th highest in terms of disability and 21st in terms of overall burden.
News article posted by: Rachael Lowe

Rachael Lowe is Co-Founder and Executive Director of Physiopedia. A physiotherapist and technology specialist Rachael has been working with Physiopedia since 2008 to create a resource that provides universal access to physiotherapy knowledge as well as a platform for connecting and educating the global physiotherapy profession.

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