Effects of TGF-B1 and IGF-1 on proliferation of human nucleus pulposus cells in medium with different serum concentrations

Rongfeng Zhang, Dike Ruan and Chao Zhang

The low proliferative viability of human nucleus pulposus(NP) cells is considered as a cause of intervertebral discs degeneration. Growth factors, such as TGF-B1 and IGF-1, have been implicated in cell proliferation and matrix synthesis. The objective of this syudy was to investigate the dose-response and time-course effect of transforming growth factor B1(TGF-B1) and insulin-like growth factor-1(IGF-1) on proliferation of NP cells .  The authors conclude that TGF-B1 and IGF-1 were efficient to stimulate cell proliferation of human NP cells in vitro with a dose- and time-dependent manner. These results support the therapeutic potentials of the two growth factors in the treatment of disc degeneration.

Journal of Orthopaedic Surgery and Research, 2006, 1:9

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