Direct effects of caffeine on osteoblastic cells metabolism: the possible causal effect of caffeine on the formation of osteoporosis

Yang-Hwei Tsuang, Jui-Sheng Sun, Li-Ting Chen, Samuel Chung-Kai Sun and San-Chi Chen

Caffeine consumption has been reported to decrease bone mineral density (BMD), increase the risk of hip fracture, and negatively influence calcium retention. This study investigates the influence of caffeine on osteoblastic behaviour in rats.  Among others, the results show that the viability of the osteoblasts and the activation of an irreversible commitment to cell death by caffeine was clearly demonstrated.  The authors conclude that caffeine has potential deleterious effect on the osteoblasts viability, which may enhance the rate of osteoblasts apoptosis.

Journal of Orthopaedic Surgery and Research 2006, 1:7.

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