Dr Shu-Fen Sun M.D, Yi-Jiun Chou M.D, Chien-Wei Hsu M.D, Chiao-Wen Hwang M.D, Pei-Te Hsu M.D, Jue-Long Wang M.D, Ya-Wen Hsu M.D. and Mei-Chia Chou M.D.
This study investigated the efficacy, safety and the duration of treatment effectiveness of intra-articular hyaluronic acid in patients with ankle osteoarthritis. It concludes that five weekly intra-articular injections of hyaluronic acid provides pain relief and functional improvements in patients with Kellgren–Lawrence grades I and II ankle osteoarthritis. The clinical effect was rapid at 1 week and may last for 6 months or more.
Osteoarthritis and Cartilage, Volume 14, Issue 9, September 2006, Pages 867-874