D.D. Greenberg M.D, A. Stoker Ph.D, S. Kane M.D, M. Cockrell and J.L. Cook D.V.M, Ph.D.
This study compared the effects of two hyaluronic acid formulations on mediators of matrix turnover and inflammation in an IL-1-treated cartilage–synovium co-culture model with the aim of elucidating mechanisms by which viscosupplementation exerts beneficial effects in osteoarthritic joints. The results support two potential mechanisms for viscosupplementation: a biosynthetic-chondroprotective mechanism, with a possible delay in onset depending on the form of hyaluronic acid; and an anti-inflammatory mechanism.
Osteoarthritis and Cartilage Volume 14, Issue 8 August 2006, Pages 814-822