Relative impact of respiratory muscle activity on tidal flow and end expiratory volume in healthy neonates

Gerard J. Hutten, Leo A. van Eykern, Philipp Latzin, Manuela Kyburz, Wim M. van Aalderen, Urs Frey.

This study investigates the hypothesis that infants dynamically regulate their tidal flow and end-expiratory volume level by studying the interaction between muscle activity, flow and lung volume in spontaneously sleeping neonates.
They measured the relative impact of intercostal and diaphragmatic EMG activity in direct comparison to the resulting tidal flow and FRC on 20 healthy babies.

Results showed that lung mechanical function is dynamically regulated and adapts on a breath to breath basis.

Pediatr Pulmonol., published on-line 30/07/2008

Link to abstract:

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