During exercise non-invasive ventilation in chronic restrictive respiratory failure.

Borel JC, Wuyam B, Chouri-Pontarollo N, Deschaux C, Levy P, Pépin JL

The objective of this study was to investigate exercise endurance and associated physiological responses with non-invasive ventilation (NIV) during exercise in restrictive CRF patients. Eighteen patients performed maximal exercise in spontaneous breathing conditions (MWLE) and during two constant workload exercise (CWLE) tests at 75% Pmax, with or without NIV in random order.  For the whole group, CWLE duration when using NIV increased which correlated with reduction in heart rate and oxygen desaturation, and dyspnea relief during exercise. NIV responders showed more severe lung restriction.  At the end of MWLE, responders had a lower Vt, a higher dead-space ratio and lower oxygen pulse.

In severely restrictive patients, NIV during exercise significantly improved exercise duration and tolerance and increased alveolar ventilation.

Respiratory Medicine, 2008, 102(5), 711-9

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