Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.

O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Piña IL,

The objective of this study was to test the efficacy and safety of exercise training among patients with heart failure. 2331 medically stable outpatients with heart failure were randomized to usual care plus aerobic exercise training, consisting of 36 supervised sessions followed by home-based training, or usual care alone. Composite primary end point of all-cause mortality or hospitalization and prespecified secondary end points of all-cause mortality, cardiovascular mortality or cardiovascular hospitalization, and cardiovascular mortality or heart failure hospitalization were measured.

Exercise training resulted in nonsignificant reductions in the primary end point of all-cause mortality or hospitalization and in key secondary clinical end points. After adjustment for highly prognostic predictors of the primary end point, exercise training was associated with modest significant reductions for both all-cause mortality or hospitalization and cardiovascular mortality or heart failure hospitalization.

JAMA. 2009, 301(14), 1439-50

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