Sudden amnesia resulting in pain relief: The relationship between memory and pain.
Choi D, Choi D, Wittington R, Nedeljkovic S. This study describes the pain experiences and treatment of two patients suffering from chronic pain who were heavily relient on analgesia who developed sudden amnesia resulting in a reduction in medication reqested and required. One patient was requiring the constant use of mophine as well as other [...]
Heritability of low back pain and the role of disc degeneration
Michele C. Battié, Tapio Videman, Esko Levalahti, Kevin Gill and Jaakko Kaprio Twin studies suggest that both disc degeneration and back pain have a genetic component. We were interested in estimating the heritability of low back pain in men and examining whether genetic influences on back pain are mediated through genetic influences on disc degeneration. [...]
The roles of sodium channels in nociception: Implications for mechanisms of pain
Theodore R. Cummins, Patrick L. Sheets and Stephen G. Waxman Understanding the role of voltage-gated sodium channels in nociception may provide important insights into pain mechanisms. Voltage-gated sodium channels are critically important for electrogenesis and nerve impulse conduction, and a target for important clinically relevant analgesics such as lidocaine. Furthermore, within the last decade studies [...]
Oxygen free radicals and tendon healing
George A.C. Murrell Nitric oxide is a small free radical generated by a family of enzymes, the nitric oxide synthases (NOSs). In a series of experiments performed over the last 15 years, we showed that nitric oxide is induced by all 3 isoforms of NOS during tendon healing and that it plays a crucial beneficial [...]
Prevalence of Lumbar Facet Arthrosis and Its Relationship to Age, Sex, and Race: An Anatomic Study of Cadaveric Specimens.
Eubanks, Jason David; Lee, Michael J.; Cassinelli, Ezequiel; Ahn, Nicholas U. Arthrosis of lumbar facet joints is a common radiographic finding and has been linked to low back pain. However, no population studies have specifically defined the prevalence of facet arthrosis in the lumbar spine in relation to age, sex, and race. The objective of [...]
Rehabilitation of Achilles and patellar tendinopathies
Alex Kountouris and Jill Cook This article discusses the rehabilitation of achilles and patellar tendinopathies. Achilles and patellar tendinopathies affect a broad range of the population and are difficult conditions to manage clinically. The pathology is persistent in the chronic tendon and can be considered to be failed healing. The exact cause of tendinopathy pain [...]
Elastin Content Correlates With Human Disc Degeneration in the Anulus Fibrosus and Nucleus Pulposus.
Cloyd, Jordan M. and Elliott, Dawn M. Recently, an abundant and organized network of elastic fibers was observed in nondegenerated human disc using immunostaining histochemistry, suggesting a functional role for elastin. While degenerative changes in the disc extracellular matrix composition are well known, changes in elastin content that may accompany degeneration have not been reported. [...]
Immediate effects on pressure pain threshold following a single cervical spine manipulation in healthy subjects.
César Fernández-de-las-Peñas, Marta Pérez-de-Heredia, Miguel Brea-Rivero, Juan C. Miangolarra-Page The objective of this syudy was to compare the immediate effects on pressure pain threshold (PPT) tested over the lateral elbow region following a single cervical high-velocity low-amplitude (HVLA) thrust manipulation, a sham-manual application (placebo), or a control condition; and to analyze if a different effect [...]
Neuronal mechanism for neuropathic pain
Min Zhuo Among different forms of persistent pain, neuropathic pain presents as a most difficult task for basic researchers and clinicians. Despite recent rapid development of neuroscience and modern techniques related to drug discovery, effective drugs based on clear basic mechanisms are still lacking. This article reviews the basic neuronal mechanisms that maybe involved in [...]
Cell Polarity in the Anulus of the Human Intervertebral Disc: Morphologic, Immunocytochemical, and Molecular Evidence.
Gruber, Helen E.; Ingram, Jane; Hoelscher, Gretchen L.; Norton, H James; Hanley, Edward N. The objective of this stucy was to determine if there is morphologic and molecular evidence for polarity in cells of the human anulus. Human disc specimens from donor and surgical patients were examined with light and electron microscopy to assess morphology. [...]
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