Efficacy and safety of pharmacological agents in managing osteoporosis in the old old: Review of the evidence
Charles A. Inderjeeth, Adrian C.H. Foo, Michelle M.Y. Lai and Paul Glendenning The objective of this review was to review the published literature on the clinical efficacy and safety of specific anti osteoporosis treatments in the reduction in fracture risk in females ? 75 years of age. Two hundred and fifty-two potentially relevant abstracts were identified. Only [...]
Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial
R.M. Rozendaal, E.J. Uitterlinden, G.J.V.M. van Osch, E.H. Garling, S.P. Willemsen, A.Z. Ginai, J.A.N. Verhaar, H. Weinans, B.W. Koes and S.M.A. Bierma-Zeinstra Recently it was reported that glucosamine sulphate (GS) did not have an effect on the symptoms and progression of primary care patients with hip osteoarthritis (OA). The aim of this present study was [...]
Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients? – a meta-analysis of randomized controlled trials
R. Christensen, E.M. Bartels, R.D. Altman, A. Astrup, H. Bliddal This review investigates Rosa canina (rosehip) preparation for symptomatic treatment of osteoarthritis (OA), in order to estimate the empirical efficacy as a pain reducing compound. RCTs from systematic searches were included if they explicitly stated that OA patients were randomized to either rosehip or placebo. [...]
Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy
Smith, M. M., Cake, M. A., Ghosh, P., Schiavinato, A., Read, R. A., Little, C. B. IA therapy with hyaluronan (HA) is reported to provide symptomatic relief and disease modification in OA. This study assessed the pathological changes in the synovium of an ovine model of OA and evaluated the effects of two HA preparations [...]
The long-term effectiveness of steroid injections in primary acromioclavicular joint arthritis: A five-year prospective study
Saqif Hossain, Leo G.H. Jacobs and Rashid Hashmi This study evaluated the long-term benefits of steroid injection in 25 shoulders in 20 consecutive patients with primary acromioclavicular arthritis. Improvement was seen at 6 months and more significant improvement at 12 months. The mean score at 5 years was a significant deterioration vs the 12-month score [...]
Withdrawal of Analgesic Medication for Chronic Low-Back Pain Patients: Improvement in Outcomes of Multidisciplinary Rehabilitation Regardless of Surgical History.
Crisostomo, Ralph A; Schmidt, John E; Hooten, W Michael; Kerkvliet, Jennifer L; Townsend, Cynthia O; Bruce, Barbara K The objective of this study was to determine the posttreatment outcomes of multidisciplinary pain rehabilitation that incorporates analgesic medication withdrawal for chronic low-back pain patients on the basis of lumbar spine surgical history. In a retrospective analysis [...]
Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues
J Monfort, J-P Pelletier, N Garcia-Giralt, J Martel-Pelletier Osteoarthritis is a chronic disease characterised by irreversible damage to joint structures, including loss of articular cartilage, osteophyte formation, alterations in the subchondral bone and synovial inflammation. Pain, functional disability and impairment of health-related quality of life are major complaints in patients with osteoarthritis. Several compounds have [...]
Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study.
S.P.Messier, S. Mihalko, R.F. Loeser, C. Legault, J. Jolla, J. Pfruender, B. Prosser, A. Adrian and J.D. Williamson This study sought to determine whether using 1500/1200mg of glucosamine hydrochloride and chondroitin sulfate (GH/CS) is effective, both separately and combined with exercise, compared to a placebo plus exercise program in improving physical function, pain, strength, balance, [...]
Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study
S.P. Messier, S. Mihalko, R.F. Loeser, C. Legault, J. Jolla, J. Pfruender, B. Prosser, A. Adrian and J.D. Williamson This study sought to determine whether using 1500/1200 mg of glucosamine hydrochloride and chondroitin sulfate (GH/CS) is effective, both separately and combined with exercise, compared to a placebo plus exercise program in improving physical function, pain, [...]
Return to top of page