In nerve-related chronic musculoskeletal (MS) disorders, neural tissue management is used to relieve pain by balancing the relative movement of neural tissues and their surrounding tissues. To date, there has not been any review evaluating the magnitude of this treatment effect in nerve-related chronic MS pain. The aim of this review was to compare pain and disability in individuals with nerve-related chronic MS pain who were treated with neural tissue management with those who received minimal or other treatment approaches. Searches of eight major electronic databases were conducted. Data for pain and disability scores were then extracted. Meta-analyses (where possible) with either a fixed- or random- effect(s) model, standardized mean differences (SMDs), and tests of heterogeneity were performed. Twenty clinical controlled trials were identified and included in the meta-analyses. When compared to minimal intervention, neural mobilization provided superior pain relief (pooled SMD -0.77, 95% confidence interval [CI] -1.11 to -0.42, P<0.0001), and reduction in disability (pooled SMD -1.06, 95% CI -1.97 to -0.14, P=0.02), after post-hoc sensitivity analyses. No significant differences were found when comparing neural mobilization to other treatment approaches for pain (pooled SMD -0.67, 95% CI -2.03 to 0.69, P=0.33), after post-hoc sensitivity analysis, and disability (pooled SMD -0.03, 95% CI -0.54 to 0.59, P=0.93).
Neural tissue management is superior to minimal intervention for pain relief and reduction of disability in nerve-related chronic MS pain. Existing evidence does not establish superiority of neural mobilization over other forms of intervention in reducing pain and disability for individuals with nerve-related chronic MS pain.