Diagnostic Instability and Reversals of COPD Diagnosis in Subjects with Mild to Moderate Airflow Obstruction.

Diagnostic Instability and Reversals of COPD Diagnosis in Subjects with Mild to Moderate Airflow Obstruction.

COPD is a chronic progressive disease and reversal of COPD diagnosis is thought to be uncommon. The objective of this study was to determine whether a spirometric diagnosis of mild or moderate COPD is subject to variability and potential error.

The authors examined two prospective cohort studies that enrolled subjects with mild to moderate post-bronchodilator airflow obstruction. The Lung Health Study (N=5861, study duration =5 years) and the CanCOLD study (N=1551, study duration = 4 years) were examined to determine frequencies of: 1) Diagnostic instability- how often patients initially met criteria for a spirometric diagnosis of COPD but then crossed the diagnostic threshold to normal and then crossed back to COPD over a series of annual visits, or vice-versa; and 2) Diagnostic reversals- how often an individual’s COPD diagnosis at the study outset reversed to normal by the end of the study.

A single post-bronchodilator spirometry assessment may not be reliable to diagnose COPD in patients with mild to moderate airflow obstruction at baseline.

Scott BuxtonResearch article posted by: Scott Buxton

My name is Scott and I am currently the editor of physiospot.

Away from the keyboard I am extended scope physiotherapist working in ED and an acute frailty unit specialising in rapid assessment and discharge of acutely unwell frail older people.

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