Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study.
S.P.Messier, S. Mihalko, R.F. Loeser, C. Legault, J. Jolla, J. Pfruender, B. Prosser, A. Adrian and J.D. Williamson
This study sought to determine whether using 1500/1200mg of glucosamine hydrochloride and chondroitin sulfate (GH/CS) is effective, both separately and combined with exercise, compared to a placebo plus exercise program in improving physical function, pain, strength, balance, and mobility in older adults with knee osteoarthritis (OA). 89 participants with knee OA were randomized to either GH/CS or placebo group. Phase I was a 6-month trial comparing the effects of assignment to either GH/CS or placebo. Phase II added 6 months of exercise for both groups. WOMAC function and pain did not differ significantly between the groups at 6- or 12-month follow-up. There were also no significant differences between the groups in 6-min walk or knee strength; however, balance was better in the placebo group with approximately a 10% difference compared to the GH/CS group.
Taking 1500/1200mg of glucosamine hydrochloride and chondroitin sulfate both separately and combined with exercise is not superior to placebo in function, pain, or mobility.
Osteoarthritis and Cartilage, 2007, 15(11), 1256-66.
- Glucosamine/chondroitin combined with exercise for the treatment of knee osteoarthritis: a preliminary study
- Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled study
- Current role of glucosamine in the treatment of osteoarthritis
- Efficacy of combined local mechanical vibrations, continuous passive motion and thermotherapy in the management of osteoarthritis of the knee.
- Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial